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The drugs' regulatory value propositions should be resolved in the near term. In the case air max 1 cheap of Provectus's lead oncology indication MM, Management has said the Company is pursuing multiple regulatory tracks: a special protocol assessment ("SPA"), accelerated approval ("AA"), and breakthrough therapy designation ("BTD"). Provectus's discussions with the FDA may be to request AA for louboutin uk Stage IIIB and IIIC patients with refractory, locally advanced disease, having sufficiently demonstrated to the Agency 's ability to safely maintain loco regional control of MM with minimal intervention and delay, reverse or prevent progression to life threatening visceral disease, and also seek christian louboutin sale uk BTD for Stage IV patients, where "sped up" discussions with dedicated senior Agency staff could help design trials to show the immediate benefits of in combination with approved MM drugs like ipilimumab (Yervoy) and vemurafenib (Zelboraf) for late stage or heavily diseased patients..